Philadelphia 76ers guard Allen Iverson will also miss because of "personal reasons", the NBA said on its website (www.nba.com), without elaborating.
Bryant will be replaced on the West squad by Dallas Mavericks guard Jason Kidd, while New York Knicks forward David Lee will take Iverson's spot on the East roster.
The game's coaches, George Karl for the West and Stan Van Gundy for the East, will determine which players start for Bryant and Iverson.
