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Hedo Turkoglu and Antoine Wright each scored 16 points as Toronto topped 100 points for the 16th consecutive game and won its seventh straight home game.
Kevin Martin scored 24 points and Spencer Hawes had 14 for the Kings, who have won just three of their past 20 and are 3-22 on the road.
Donte Greene scored 13 points while Tyreke Evans and Andres Nocioni each had 11 for Sacramento.
Bosh made 14 of 18 field goal attempts and went 8 for 11 from the foul line as the Raptors won for the 13th time in 14 home games.
Sacramento's Sean May made two jumpers to open the fourth quarter, giving the Kings a 91-84 lead, but Toronto scored the next eight points, including a three-point play by Bosh and a breakaway dunk by Sonny Weems , to lead 92-91 with 10:04 remaining.
It stayed close until Bosh made a layup and a pair of free throws and Wright sandwiched a jumper and a corner 3 around a free throw by Greene, putting Toronto up 105-97 with 4:12 left.
Toronto welcomed Turkoglu and DeMar DeRozan back to the starting lineup after injuries. Turkoglu wore a mask to protect the fractured orbital bone that kept him out of the past two games, while DeRozan had missed five games with a sprained right ankle. Jose Calderon , who missed one game with a right ankle sprain, also returned, but Marco Belinelli was scratched with a sore left ankle.
Turkoglu had been reluctant to wear the mask but changed his mind Saturday. He was hot early, scoring nine points in the first as Toronto made nine of its first 11 field goal attempts.