They bowed out of the French Cup on a snow-covered pitch to goals scored from close range by Mali international and former Liverpool player Djimi Traore in the 27th minute and Nigerian Moussa Maouzou in the 53rd.
Olympique Marseille also crashed out of the competition in the snow through a 3-1 defeat at Racing Lens in a rescheduled last 32 match.
Tunisian striker Issam Djemaa scored twice in the first half and Toifilou Maoulida sealed Lens' victory in the 57th minute. Benoit Cheyrou saved some pride for Marseille four minutes later.
Saint-Etienne and AJ Auxerre dispatched second division Vannes 2-0 and third division Plabennec 4-0 respectively to reach the quarter-finals but another Ligue 1 team Toulouse failed to make the last 16, losing 2-0 to second division Brest.